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Health-Related Quality of Life after Ischemic Stroke: The Impact of Pharmaceutical Interventions on Drug Therapy (Pharmaceutical Care Concept)

Carina Hohmann12*, Roland Radziwill2, Juergen M Klotz1 and Andreas H Jacobs3

Author Affiliations

1 Klinikum Fulda gAG, Department of Neurology, Pacelliallee 4, 36043 Fulda, Germany

2 Klinikum Fulda gAG, Department of Pharmacy and Patient Counselling, Pacelliallee 4, 36043 Fulda, Germany

3 European Institute for Molecular Imaging - EIMI, University of Muenster, Technologiehof L1, Mendelstrasse 11, 48149 Muenster, Germany

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Health and Quality of Life Outcomes 2010, 8:59  doi:10.1186/1477-7525-8-59

Published: 18 June 2010



Health-related quality of life (HRQoL) after stroke is an important healthcare measure. Pharmaceutical Care (PC) is an evolving concept to optimize drug-therapy, minimize drug-related problems, and improve HRQoL of patients. The purpose of this study was to evaluate the impact of PC on HRQoL, as determined by Short Form 36 (SF-36) among patients after TIA or ischemic stroke one-year following their initial entry in hospital.


Patients were assigned to either an intervention (IG) or a control group (CG). The individual assignment of the patient to IG or CG depended on the community pharmacy to which the patients were assigned for care. Community pharmacies either delivered standard care (CG) or provided intensified PC (IG). Pharmacists who are members of the "Quality Assurance Working Group" (QAWG) provided PC for patients in IG.


255 patients were recruited (IG: n = 90; CG: n = 165) between 06/2004 to 01/2007. During the study, the HRQoL of the patients in IG did not change significantly. In the CG, a significant decrease in the HRQoL was observed in 7/8 subscales and in both summary measures of SF-36.


This is the first follow-up study in Germany involving a major community hospital, rehabilitation hospitals, community pharmacies and general practitioners investigating the impact of PC on HRQoL of patients after ischemic stroke. Our findings indicate that an intensified education and care of patients after ischemic stroke by dedicated pharmacists based on a concept of PC may maintain the HRQoL of IG patients.