A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change

doi:10.1186/1477-7525-7-17

Health and Quality of Life Outcomes

Volume 7

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von Gruenigen VE
Gibbons HE
Kavanagh MB
Janata JW
Lerner E
Courneya KS

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Gibbons HE
Kavanagh MB
Janata JW
Lerner E
Courneya KS
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Research

A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change

Vivian E von Gruenigen¹^,2 , Heidi E Gibbons¹^,2 , Mary Beth Kavanagh³ , Jeffrey W Janata¹^,2^,4 , Edith Lerner³ and Kerry S Courneya⁵

¹University Hospitals Case Medical Center, Cleveland, OH, USA

²Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH, USA

³Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA

⁴Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA

⁵Department of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada

author email corresponding author email

Health and Quality of Life Outcomes 2009, 7:17doi:10.1186/1477-7525-7-17


Published:	25 February 2009

Abstract

Background

To examine the effects of a 6 month lifestyle intervention on quality of life, depression, self-efficacy and eating behavior changes in overweight and obese endometrial cancer survivors.

Methods

Early stage endometrial cancer survivors were randomized to intervention (n = 23) or usual care (n = 22) groups. Chi-square, Student's t-test and repeated measures analysis of variance were used in intent-to-treat analyses. Outcomes were also examined according to weight loss.

Results

Morbidly obese patients had significantly lower self-efficacy, specifically when feeling physical discomfort. There was a significant improvement for self-efficacy related to social pressure (p = .03) and restraint (p = .02) in the LI group. There was a significant difference for emotional well-being quality of life (p = .02), self-efficacy related to negative emotions (p < .01), food availability (p = .03), and physical discomfort (p = .01) in women who lost weight as compared to women who gained weight. Improvement in restraint was also reported in women who lost weight (p < .01).

Conclusion

This pilot lifestyle intervention had no effect on quality of life or depression but did improve self-efficacy and some eating behaviors.

Trial Registration

http://www.clinicaltrials.gov webcite; NCT00420979