|
GSRS and GIQLI scores by physician's rating of clinical disease severity at baseline |
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| Groups by rating of clinical severity |
Kruskall-Wallis Test of overall differences |
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| Patient reported outcome instrument and domain |
None (n = 20) mean (SD) |
Mild (n = 6) mean (SD) |
Moderate (n = 32) mean (SD) |
Severe (n = 4) mean (SD) |
Chi-Square |
p-value |
Wilcoxon rank-sum tests (pairwise comparisons with p < 0.001) |
|
|
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| GSRS Abdominal Pain |
1.33 (0.42) |
2.61 (0.93) |
3.29 (1.23) |
3.83 (1.69) |
33.75 |
<0.001 |
b |
| GSRS Reflux Syndrome |
1.10 (0.26) |
2.42 (1.32) |
3.09 (1.46) |
4.00 (2.12) |
29.25 |
<0.001 |
b, c |
| GSRS Diarrhea |
1.12 (0.20) |
3.61 (1.69) |
3.57 (1.56) |
2.67 (1.70) |
37.21 |
<0.001 |
a, b |
| GSRS Indigestion Syndrome |
1.29 (0.33) |
3.29 (1.81) |
3.76 (1.43) |
4.81 (1.68) |
38.29 |
<0.001 |
a, b |
| GSRS Constipation |
1.20 (0.38) |
1.94 (0.65) |
2.55 (1.26) |
3.42 (2.23) |
27.03 |
<0.001 |
b |
| GIQLI Total Score |
126.00 (10.97) |
95.83 (23.22) |
87.02 (22.08) |
65.00 (37.37) |
33.25 |
<0.001 |
b |
| GIQLI Symptoms |
3.64 (0.30) |
2.65 (0.68) |
2.49 (0.57) |
1.87 (0.82) |
35.31 |
<0.001 |
b |
| GIQLI Emotion |
3.24 (0.64) |
2.87 (0.70) |
2.47 (0.74) |
1.60 (0.86) |
16.33 |
<0.001 |
|
| GIQLI Physical Function |
3.21 (0.61) |
2.14 (0.89) |
1.92 (0.91) |
1.61 (1.62) |
22.00 |
<0.001 |
b |
| GIQLI Social Function |
3.55 (0.60) |
3.04 (0.70) |
2.74 (0.96) |
2.19 (1.60) |
10.22 |
0.017 |
|
| GIQLI Medical Treatment |
3.95 (0.22) |
4.00 (0.00) |
2.94 (1.11) |
1.50 (1.91) |
21.25 |
<0.001 |
b, c |
|
Comparisons not significant unless noted. a = none vs. mild; b = none vs. moderate; c = none vs. severe; d = mild vs. moderate; e = mild vs. severe; f = moderate vs. severe. | |||||||
Machnicki et al. Health and Quality of Life Outcomes 2008 6:53 doi:10.1186/1477-7525-6-53 |
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