Table 4

Predictors of Physical health MSQoL-54 scales by IFN-β treatment (Multivariate hierarchical analysis)

Energy
 Health perceptions
 Physical function
 Role limitation physical
 Bodily pain
 Social function
Effect
 β
 p
 β
 p
 β
 p
 β
 p
 β
 p
 β
 p
Intercept*
 45.11
 <.0001
 44.67
 <.0001
 69.40
 <.0001
 71.72
 <.0001
 74.23
 <.0001
 72.54
 <.0001
Age at inclusion
 -0.12
 0.36
 0.06
 0.68
 -0.4
 0.01
 -0.60
 0.03
 -0.36
 0.04
 0.06
 0.66
Gender (Male vs. Female)
 -0.51
 0.84
 2.00
 0.52
 1.07
 0.75
 -17.3
 0.003
 3.74
 0.31
 -0.32
 0.90
Disease duration
 -0.02
 0.92
 -0.36
 0.08
 0.10
 0.64
 0.19
 0.60
 -0.38
 0.12
 -0.30
 0.10
Disease course (SP vs. RR)
 9.54
 0.03
 7.35
 0.16
 -8.44
 0.12
 8.77
 0.34
 17.33
 0.004
 8.65
 0.06
Relapse rate 2-yrs before study entry
 0.37
 0.90
 -2.01
 0.58
 0.70
 0.86
 1.39
 0.83
 -0.20
 0.96
 3.76
 0.24
EDSS
 -2.33
 0.06
 -3.54
 0.02
 -8.44
 <.0001
 -4.69
 0.09
 -2.82
 0.11
 -2.65
 0.05
BDI
 -1.16
 <.0001
 -0.26
 0.20
 0.25
 0.26
 -0.92
 0.01
 0.22
 0.36
 -0.66
 0.0004
FSS
 -4.80
 <.0001
 -6.8
 <.0001
 -8.69
 <.0001
 -10.0
 <.0001
 -9.74
 <.0001
 -6.72
 <.0001
MMSE-c
 -0.19
 0.71
 -0.43
 0.46
 0.05
 0.94
 -1.90
 0.10
 0.02
 0.98
 -0.30
 0.57
IFN-β treatment (Yes vs No)
 1.43
 0.65
 3.56
 0.32
 1.20
 0.77
 5.03
 0.50
 4.54
 0.32
 0.23
 0.94
Relapse rate change after 2-yrs
 4.96
 0.17
 2.40
 0.61
 3.76
 0.20
 -2.71
 0.69
 2.96
 0.54
 6.77
 0.08
EDSS change after 2-yrs
 -0.11
 0.95
 -1.49
 0.54
 -4.54
 0.003
 0.59
 0.86
 0.70
 0.77
 -2.72
 0.16
BDI change after 2-yrs
 -0.67
 0.0005
 -0.48
 0.05
 -0.14
 0.37
 -1.59
 <.0001
 -0.82
 0.002
 -0.67
 0.001
FSS change after 2-yrs
 -5.20
 <.0001
 -4.89
 0.001
 -4.65
 <.0001
 -4.75
 0.03
 -5.98
 0.0001
 -4.39
 0.0003
MMSE-c change after 2-yrs
 -1.09
 0.15
 0.20
 0.84
 -0.10
 0.87
 -3.04
 0.04
 -0.64
 0.53
 0.18
 0.81
Time**
 8.67
 0.004
 3.36
 0.37
 -4.84
 0.05
 -1.00
 0.86
 -1.81
 0.65
 0.64
 0.84
Time × IFN-β treatment (Yes vs No)
 -0.76
 0.86
 -1.72
 0.74
 -6.15
 0.07
 -2.54
 0.77
 3.82
 0.50
 -1.73
 0.69

*Intercept value represents the baseline mean score for reference group (Untreated)

**Time value represents the mean score change for reference group (Untreated) after 2 years of follow-up

Simone et al. Health and Quality of Life Outcomes 2006 4:96   doi:10.1186/1477-7525-4-96