|
Predictors of MSQoL-54 composite scores by IFN-β treatment (Multivariate hierarchical analysis) |
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| Physical Health Composite Score |
Mental Health Composite Score |
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|
|
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| Effect |
β |
p |
β |
p |
| Intercept* |
65.08 |
<.0001 |
69.31 |
<.0001 |
| Age at inclusion |
-0.19 |
0.043 |
-0.22 |
0.06 |
| Gender (Male vs. Female) |
-1.51 |
0.43 |
-6.95 |
0.005 |
| Disease duration |
-0.1 |
0.41 |
-0.04 |
0.82 |
| Disease course (SP vs. RR) |
3.69 |
0.24 |
8.39 |
0.037 |
| Relapse rate 2-yrs before study entry |
0.69 |
0.75 |
0.62 |
0.83 |
| EDSS |
-3.44 |
0.0003 |
-0.85 |
0.47 |
| BDI |
-0.59 |
<.0001 |
-1.44 |
<.0001 |
| FSS |
-6.69 |
<.0001 |
-2.08 |
0.019 |
| MMSE-c |
-0.28 |
0.44 |
0.45 |
0.34 |
| IFN-β treatment (Yes vs No) |
-0.09 |
0.97 |
2.75 |
0.36 |
| Relapse rate change after 2-yrs |
2.15 |
0.42 |
0.60 |
0.84 |
| EDSS change after 2-yrs |
-1.57 |
0.26 |
1.59 |
0.31 |
| BDI change after 2-yrs |
-0.60 |
<.0001 |
-1.08 |
<.0001 |
| FSS change after 2-yrs |
-5.21 |
<.0001 |
-2.48 |
0.01 |
| MMSE-c change after 2-yrs |
-0.35 |
0.53 |
-0.16 |
0.81 |
| Time** |
1.32 |
0.54 |
3.33 |
0.19 |
| Time × IFN-β treatment (Yes vs No) |
-1.65 |
0.58 |
-9.19 |
0.01 |
|
*Intercept value represents the baseline mean score for reference group (Untreated) **Time value represents the mean score change for reference group (Untreated) after 2 years of follow-up | ||||
Simone et al. Health and Quality of Life Outcomes 2006 4:96 doi:10.1186/1477-7525-4-96 |
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