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Open Access Research

Reliability and validity of the Chinese version of the pediatric quality of life inventoryTM (PedsQLTM) 3.0 neuromuscular module in children with Duchenne muscular dystrophy

Jun Hu1234, Li Jiang1234*, Siqi Hong1234, Li Cheng1234, Min Kong1234 and Yuanzhen Ye1234

Author Affiliations

1 Ministry of Education Key Laboratory of Child Development and Disorders, Children’s Hospital, Chongqing Medical University, No. 136 Zhongshan Er Road, Yuzhong District, Chongqing, China

2 Key Laboratory of Pediatrics in Chongqing, Children’s Hospital, Chongqing Medical University, No. 136 Zhongshan Er Road, Yuzhong District, Chongqing, China

3 Chongqing International Science, Technology Cooperations Center for Child Development and Disorders, Children’s Hospital, Chongqing Medical University, No. 136 Zhongshan Er Road, Yuzhong District, Chongqing, China

4 Department of Neurology, Children’s Hospital, Chongqing Medical University, No. 136 Zhongshan Er Road, Yuzhong District, Chongqing, China

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Health and Quality of Life Outcomes 2013, 11:47  doi:10.1186/1477-7525-11-47

Published: 15 March 2013

Abstract

Background

The Pediatric Quality of Life InventoryTM (PedsQLTM) is a widely used instrument to measure pediatric health-related quality of life (HRQOL) in children aged 2 to 18 years. The current study aimed to evaluate the reliability and validity of the Chinese version of the PedsQLTM 3.0 Neuromuscular Module in children with Duchenne muscular dystrophy (DMD).

Methods

The PedsQLTM 3.0 Neuromuscular Module was translated into Chinese following PedsQLTM Measurement Model Translation Methodology. The Chinese version scale was administered to 56 children with DMD and their parents, and the psychometric properties were evaluated.

Results

The missing value percentages for each item of the Chinese version scale ranged from 0.00% to 0.54%. Internal consistency reliability approached or exceeded the minimum reliability standard of α = 0.7 (child α = 0.81, parent α = 0.86). Test-retest reliability was satisfactory, with intraclass correlation coefficients (ICCs) of 0.66 for children and 0.88 for parents (P < 0.01). Correlation coefficients between iteims and their hypothesized subscales were higher than those with other subscales (P < 0.05). The subscale of “About My/My Child’s Neuromuscular Disease” significantly related to mobility and stair climbing status (Child t = 2.21, Parent t = 2.83, P < 0.05). The inter-correlations among the Chinese version of the PedsQLTM 3.0 Neuromuscular Module and the PedsQLTM 4.0 Generic Core Scales had medium to large effect sizes (P < 0.05). The child self-report scores were in moderate agreement with the parent proxy-report scores (ICC = 0.51, P < 0.05).

Conclusions

The Chinese version of the PedsQLTM 3.0 Neuromuscular Module has acceptable psychometric properties. It is a reliable measure of disease-specific HRQOL in Chinese children with DMD.

Keywords:
Duchenne muscular dystrophy; Pediatric quality of life inventoryTM; Neuromuscular module; Chinese version; Reliability; Validity