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Quality of life profile and psychometric properties of the EQ-5D-5L in HIV/AIDS patients

Bach Xuan Tran12*, Arto Ohinmaa1 and Long Thanh Nguyen3

  • * Corresponding author: Bach X Tran

  • † Equal contributors

Author Affiliations

1 School of Public Health, University of Alberta, Alberta, Canada

2 Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam

3 Authority of HIV/AIDS Control, Ministry of Health, Hanoi, Vietnam

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Health and Quality of Life Outcomes 2012, 10:132  doi:10.1186/1477-7525-10-132

Published: 1 November 2012



We assessed health-related quality of life (HRQOL), its associated factors, and examined measurement properties of the EuroQol - 5 Dimensions - 5 Levels (EQ-5D-5L) in HIV/AIDS patients.


A cross-sectional multi-site survey was conducted in 1016 patients (age: 35.4 ± 7.0 years; 63.8% male) in three epicenters of Vietnam. Internal consistency reliability, convergent validity, and discriminative validity of the EQ-5D-5L and a visual analogue scale (VAS) were evaluated. Tobit censored regression models were used to identify predictors of HRQOL in HIV/AIDS patients.


The mean EQ-5D-5L single index and VAS were 0.65 (95% Confidence Interval (CI) = 0.63; 0.67) and 70.3 (95% CI = 69.2; 71.5). Cronbach’s alpha of five dimensions was 0.85. EQ-5D-5L has a good convergent validity with VAS (0.73). It discriminated patients at different HIV/AIDS stages, duration of ART, and CD4 cell count. Predictors of poorer HRQOL included being female, lower education level, unemployment, alcohol and drug use, CD4<200 cells/mL, and advanced HIV/AIDS stages.


The EQ-5D-5L has good measurement properties in HIV/AIDS patients and holds potentials for monitoring ART outcomes. Integration of HRQOL measurement using EQ-5D-5L in HIV/AIDS clinical practice could be helpful for economic evaluation of HIV/AIDS interventions.

EQ-5D; Quality of life; Utility; HIV; Vietnam; Psychometric properties; Antiretroviral treatment