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Analyses of Variance of Patient Reported Outcome Measures Among Three Groups of PASI Improvement Scores:≥ 75%; Between 50% and 75%; and < 50%. |
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| STUDY A |
STUDY B |
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| Mean Change Score (N) |
Mean Change Score (N) |
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| Outcome Measure |
<50% |
≥50% and <75% |
≥75% |
F statistic |
p value |
< 50% |
≥50% and <75% |
≥75% |
F statistic |
p value |
|
|
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| PSA Frequency (8 items) |
2.38 (232) |
6.48 (97) |
8.75 (110) |
61.71 |
<0.0001 |
2.35 (269) |
7.16 (149) |
9.71 (125) |
85.65 |
<0.0001 |
| PSA Frequency (7 items) |
1.90 (232) |
5.15 (97) |
7.12 (111) |
49.81 |
<0.0001 |
1.90 (269) |
5.94 (149) |
7.98 (125) |
72.61 |
<0.0001 |
| PSA Severity (8 items) |
2.45 (231) |
7.05 (97) |
9.93 (111) |
69.06 |
<0.0001 |
2.52 (271) |
7.87 (149) |
10.52 (125) |
88.46 |
<0.0001 |
| PSA Severity (7 items) |
1.95 (231) |
5.76 (97) |
8.19 (111) |
58.82 |
<0.0001 |
2.05 (271) |
6.47 (149) |
8.79 (125) |
77.04 |
<0.0001 |
| PSA TOTAL Scale (16 items) |
4.79 (230) |
13.53 (96) |
18.63 (110) |
69.76 |
<0.0001 |
4.88 (269) |
15.03 (149) |
20.23 (125) |
91.77 |
<0.0001 |
| DLQI TOTAL |
2.48 (223) |
5.33 (97) |
9.57 (104) |
54.61 |
<0.0001 |
2.49 (268) |
6.83 (146) |
10.03 (122) |
75.05 |
<0.0001 |
| DLQI Symptom and Feelings |
0.74 (235) |
1.70 (98) |
2.94 (110) |
69.64 |
<0.0001 |
0.79 (271) |
2.14 (150) |
2.95 (127) |
94.27 |
<0.0001 |
| DLQI Daily Activities |
0.45 (234) |
1.13 (98) |
2.14 (110) |
41.11 |
<0.0001 |
0.61 (270) |
1.47 (150) |
2.17 (127) |
42.37 |
<0.0001 |
| DLQI Leisure |
0.40 (235) |
0.96 (98) |
1.81 (111) |
27.70 |
<0.0001 |
0.60 (271) |
1.08 (150) |
1.89 (126) |
22.34 |
<0.0001 |
| DLQI Work and School |
0.28 (226) |
0.46 (97) |
0.62 (106) |
5.41a |
<0.0001 |
0.17 (269) |
0.52 (147) |
0.73 (123) |
16.44b |
<0.0001 |
| DLQI Personal Relationships |
0.20 (236) |
0.45 (98) |
1.20 (111) |
17.89 |
<0.0001 |
0.12 (271) |
0.75 (150) |
1.21 (126) |
25.21 |
<0.0001 |
| DLQI Treatment |
0.22 (236) |
0.65 (98) |
1.05 (111) |
24.90 |
<0.0001 |
0.14 (271) |
0.81 (149) |
1.08 (126) |
41.70b |
<0.0001 |
| NPF Itch Scale |
n/a |
n/a |
n/a |
n/a |
n/a |
0.59 (273) |
1.65 (150) |
2.34 (127) |
58.13 |
<0.0001 |
| VAS Itch Scale |
0.79 (235) |
2.97 (98) |
4.34 (111) |
56.96 |
<0.0001 |
n/a |
n/a |
n/a |
n/a |
n/a |
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Note: Post-hoc comparisons of groups indicate all groups differ from one another for each of the measures, p < .05, unless otherwise specified. a PASI change ≥75% different from PASI change <50% only. b PASI change ≥75% not significantly different from middle group (PASI change ≥50% and <75%. | ||||||||||
Shikiar et al. Health and Quality of Life Outcomes 2003 1:53 doi:10.1186/1477-7525-1-53 |
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